Nucleosome containing histone H3 mutant K36A is not a substrate. Please wait a moment until the data is sorted. At the top of the view, the position of the antigen identified by the corresponding HPA identifier is shown as a green bar. Genes with no secreted transcripts according to either the analysis of predictions or uniprot localization data will have the localization s predicted for the transcripts. Polycomb repressive complex 2.
Histone methyltransferase with histone H3 'Lys' (H3K27me) Enzyme and pathway databases Histone-lysine N-methyltransferase NSD2 (EC). An activating mutation of the NSD2 histone methyltransferase drives oncogenic The EK mutation altered enzyme/substrate binding and. The histone lysine methyltransferase nuclear receptor-binding SET domain ( NSD) family of histone lysine methyltransferase enzymes, NSD1.
GO [zinc ion binding] GO [metal ion binding] Show all. Esophagus Squamous epithelial cells:. To access sample data, click on tissue name or bar. Functional Parameters. Yes No.
Nsd2 methyltransferase enzyme
Gene description according to HGNC. Genes with no secreted transcripts according to either the analysis of predictions or uniprot localization data will have the localization s predicted for the transcripts.
Genes with no secreted transcripts according to either the analysis of predictions or uniprot localization data will have the localization s predicted for the transcripts. Adrenal gland Glandular cells:. Mus musculus.
Protein methyltransferases are enzymes that add covalent methyl (also known as NSD2 or MMSET), and WHSC1L1 (also known as NSD3).
N1- 2- 6-methoxy 4-methyl-1,4-diazepanyl 1-methylpiperidinylamino quinazolinyloxy ethyl -N1,N2,N2-trimethylethane-1,2-diamine. N-cyclohexyl-6,7-dimethoxy 4-methyl-1,4-diazepanyl -quinazolinamine.
Some transcript variants are nonsense-mediated mRNA NMD decay candidates, hence not represented as reference sequences. Appendix Glandular cells:. Several cases of colorectal cancer, melanoma along with rare lung, testis, urothelial, stomach and pancreatic cancers showed strong positivity. This gene maps to the kb WHS critical region and has also been involved in the chromosomal translocation t 4;14 p Schizosaccharomyces pombe.
Nsd2 methyltransferase enzyme
Protein class es of the gene product according to selected gene lists.
BRENDA Information on EC histonelysine Nmethyltransferase
At the top of the view, the position of the antigen identified by the corresponding HPA identifier is shown as a green bar. Read more TCGA cancer tissue :. Gene information from Ensembl and Entrezas well as links to available gene identifiers are displayed here.
Keywords: NSD2, PARP1, histone, methylation, DNA damage, PARylation, protein complex.
Accordingly, an enzyme shearing cocktail is. EK) in the NSD2 SET domain that confers increased catalytic efficiency of this enzyme, resulting in elevated levels of H3K36me2 (19).
N-cyclopropyl-6,7-dimethoxy 4-methyl-1,4-diazepanyl -quinazolinamine.
The curve in blue displays the predicted antigenicity i. A summary of the overall protein expression pattern across the analyzed normal tissues.
Video: Nsd2 methyltransferase enzyme Methyltransferase Assays
Seminal vesicle Glandular cells:. Schizosaccharomyces pombe.
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PRDM8 repressed the expression of steroidogenic markers, pc17c and luteinizing hormone receptor, which indicates its regulatory role in mouse testis development and steroidogenesis. Esophagus Squamous epithelial cells:.
The protein information section displays alternative protein-coding transcripts splice variants encoded by this gene according to the Ensembl database.
Video: Nsd2 methyltransferase enzyme Protein Methyltransferase Inhibitors as Personalized Cancer Therapeutics
Gene information from Ensembl and Entrezas well as links to available gene identifiers are displayed here. Set9 methyltransferase.